
Nanos and dental care

Nanos and dental care
By AVICENN Team – Last Added July 2022
What nanomaterials can be found in dental products?
In the field of dentistry as in the others, it is difficult today to distinguish the “promises” still in the state of research & development from the nano applications actually marketed. Nanoparticles have been used in dental composites for decades.
In France, the 2017 R-Nano report counts three “entities” (companies) having declared nano for “manufacture of instruments and supplies for medical and dental use”.
It makes it possible to identify several substances declared in nanoparticle form as used in the manufacture of "dental products" (or "for dental use"): aluminum oxide, iron oxide, silica (without however providing further details on the manufacturers or the type of products, the properties or the quantity of nano-registered substances).
According to Mr. Gardon-Mollard, Doctor of Dental Surgery, in dental offices, we would find nanoparticles1Who's Afraid of Toxic Dental Materials?, The Dentalist, October 2019:
- about sealing cements (zinc oxyphosphates, CVIMAR…)
- about calcium silicates (Biodentin)
- about impression materials (elastomers)
- about composites and adhesives, dispersed mainly during polishing operations if these are carried out without spray or suction.

- In French :
- Dental nanoparticles and biomaterials, Elisabeth Dursun, 21st public health day, ASPBD, November 4, 2021 (from the 33rd minute)
- Invention: Making smiles thanks to nanomaterials, European Patent Office (EPO), April 2021
- Nanoparticles – Part 1: Description, potential health risks and applications in dentistry, Julie Gorse, Jean-Pierre Attal, Elisabeth Dursun, Clinical BioMaterials, 6(1), March 2021
- Nanoparticles in dentistry, Julie Gorse, thesis, University of Paris, UFR of odontology – Montrouge, November 2020
- Development of dental adhesive manufacturing technology in Iran, IRNA (Iran), September 2020
- Who's Afraid of Toxic Dental Materials?, The Dentalist, October 2019
- Contribution of nanotechnology to the treatment of periodontitis: systematic literature review, Thesis of Nicolas Moignot, Paris Descartes University, Life Sciences, 2019
- An army of microrobots to clean dental plaque, Futura Sciences, May 2, 2019: "Microrobots made from iron oxide nanoparticles can remove bacterial biofilms while being precisely directed by magnets"
- Fillings "for life", now a reality?, Sputnik France, January 31, 2018: Canadian researchers have developed a new type of filling that protects teeth against microbial attacks using nanoparticles of antibiotics incorporated into the filling, the journal announces Nature Communications
- Nanos: a filling that kills bacteria and remineralizes the tooth, Engineering techniques, May 2012: calcium phosphate nanoparticles (to regenerate tooth minerals) and silver nanoparticles (antibacterial).
- Nanoparticles in dental products, Candulor, date?
- Biological evaluation of medical devices containing nanomaterials, Afssaps (now ANSM), February 2011 (“Dental and orthopedic products”, pages 21-24)
- In English :
- UQ's advanced nanotechnology to improve success of dental implants, The University of Queensland, June 11, 2020
- Applications of nano-materials in various dentistry regimes, Foong L et al., RSC Adv., 10: 15430-15460, 2020
- Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation, Nanomaterials, Carrouel F et al., 10(1), 140, 2020
- Mathym's products, currently used in dental products (France), date?
- Researchers use antibacterial nanoparticles to prolong dental restorations, Dental Tribune, May 10, 2019
- “A safe and effective way to whiten teeth with nanoparticles”, Nanowork with American Chemical Society (ACS), July 2018
- Nanoparticles used in dentistry: A review, Priyadarsini S et al., Journal of Oral Biology and Craniofacial Research, 8(1): 58-67, 2018
- Metal TiO2 nanotube layers for the treatment of dental implant infections, Roguska A et al., ACS Applied Materials & Interfaces 2018
- Application of Nanomaterials in Dentistry, Qasim S., Rehman IU, in: Micro and Nanomanufacturing, Volume II, Jackson M., Ahmed W. (eds) Springer, Cham, 2018
- to complete…
What do we know about the associated risks?
Exposure pathways and risks
Few “general public” resources on risks specifically related to nanoparticles in dental products are available online.
According to the professionals, the nanoparticles are confined in a resin which, once hardened, prevents the nanoparticles from detaching. Only a very small number of nanoparticles would be likely to be ingested, following wear or abrasion of the products – but in much lower proportions than those fromfood to toothpaste, lipsticks and balms, etc.
But what is true for consumers is less true for professionals: as the European Agency for Safety and Health at Work points out, " the milling, drilling, grinding and polishing of applied medical materials containing nanomaterials during dental and surgical procedures represent possible exposure situations. This is the case, for example, with the treatment of caries in dental care, for which fillings containing nanomaterials (e.g. nanoceramic fillings) are usually placed, which are adjusted to the anatomical shape by grinding the surface with the help of high-speed tools. During this procedure, there is a risk that nanoparticles will disperse into the air and be inhaled by the patient and the medical staff.”2Nanomaterials in the healthcare sector: occupational risks and their prevention, EU OSHA, E-facts 73, 2013.
These situations of exposure to nanomaterials exist throughout the life cycle of the material. The prosthetist, during the development of the material, can be exposed to it by inhalation. In the case of polishing or depositing a material, it is the patient and the practitioner who may be exposed to it, by inhalation – and to a lesser extent by swallowing for the patient.3See intervention by Prof. Élisabeth Dursun, “ Dental nanoparticles and biomaterials " when 21st public health day, organized by the ASPBD on November 4, 2021, 0:45′.
However, it is still too rare to see real benefit/risk approaches and prevention seems very weak to date.
- In French :
- Dental nanoparticles and biomaterials, Elisabeth Dursun, 21st public health day, ASPBD, November 4, 2021 (from the 33rd minute)
- Guide to the eco-responsible health practice, Alice Baras, EHESP Press, October 2021
- Eco-responsible approach to the dental office, Alice Baras, French Dental Association (ADF), September 2021
- Nanoparticles in dentistry, Julie Gorse, thesis, University of Paris, UFR of odontology – Montrouge, November 2020
- Who's Afraid of Toxic Dental Materials?, The Dentalist, October 2019
- After food, the suspension of titanium dioxide in toothpastes and medicines?, AVICENN, Veillenanos.fr, March 2019
- Investigation report on the presence of titanium dioxide in toothpaste, Acting for the Environment, March 2019
- Nanoparticles in dental products, Candulor, date?
- In English :
- Progress of Nanomaterials in Preventative and Restorative Dentistry, Rattan S et al., Recent Progress in Materials 2022
-
Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation, Nanomaterials, Carrouel F et al., 10(1), 140, 2020
- Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and dental hygienists in Norway, Xenaki V et al., Acta Odontologica Scandinavica, 78 (2), 2020
- Nanomaterials in dentistry: a cornerstone or a black box?, Pokrowiecki R et al., Nanomedicine, 13 (6), 2018
- Can degradation products released from dental implants affect peri‐implant tissues?, Noronha Oliveira M et al., Journal of periodontal research, 53(1): 1-11, February 2018
- Histologic investigation of cytotoxicity of nanocomposite particles used for direct restorations in dentistry in rat models, Gimaletdinova AM et al., Kazan medical journal, 98 (5), 2017
- Biological evaluation of medical devices containing nanomaterials, Afssaps (now ANSM), February 2011 (“Dental and orthopedic products”, pages 21-24)
- to complete…
What precautionary measures?
Some precautionary operating measures can be adopted during milling, polishing, etc. operations. to limit, ultimately, exposure to nanomaterials. Elisabeth Dursun quotes some of them in her November 2021 speech4See intervention by Prof. Élisabeth Dursun, “ Dental nanoparticles and biomaterials organized by the ASPBD on November 4, 2021 during the 21st public health day, based on recommendations from the Francophone Society of Dental Biomaterials (SFBD):
- sculpt the restoration in detail before setting, to reduce the amount of milled material for finishing and polishing
- use water to cool and vacuum more effectively during polishing
- ventilate the premises frequently
- protect staff:
- wear an FFP3 mask when polishing, as well as glasses
- ask assistants to step away when polishing
- prefer powder/liquid capsule systems
- use rubber dam for finishing when occlusion is not in play
- pay particular attention to vulnerable patients (asthma, chronic bronchial obstruction, etc.)
A remark, a question? This sheet produced by AVICENN is intended to be supplemented and updated. Please feel free to contribute.
The next nano appointments
- 14th meeting of the “nano and health” dialogue committee
- Organizer: ANSES
- Website : www.anses.fr
- Technical Day
- Organizer: National Metrology and Testing Laboratory (LNE)
- On the agenda: identification of nanomaterials, recent technological innovations in terms of particle size characterization, areas for progress to be considered
- Upcoming program
- Website : www.lne.fr/…
- 8th International Conference on Health Issues for a Responsible Approach to Nanomaterials
- June 5-9, 2023
- Organizer: Commissariat for Atomic Energy and Alternative Energies (CEA)
- Website : www.cea.fr/cea-tech/pns/nanosafe/…
This listing was originally created in February 2019
Notes & references
- 1Who's Afraid of Toxic Dental Materials?, The Dentalist, October 2019
- 2Nanomaterials in the healthcare sector: occupational risks and their prevention, EU OSHA, E-facts 73, 2013
- 3See intervention by Prof. Élisabeth Dursun, “ Dental nanoparticles and biomaterials " when 21st public health day, organized by the ASPBD on November 4, 2021, 0:45′
- 4See intervention by Prof. Élisabeth Dursun, “ Dental nanoparticles and biomaterials organized by the ASPBD on November 4, 2021 during the 21st public health day