
Life cycle of nanomaterials and nano-enhanced products

Consider the entire life cycle of nanomaterials and nano enhanced products
By the AVICENN team – Last updated May 2024
In order to not to repeat the mistakes of the past, it is necessary that industrialists, risk assessment and management authorities and researchers consider the entire life cycle of nanomaterials: from initial production, usage or consumption to destruction or recycling.
A comprehensive approach – social life cycle assessment (SLCA) – is being promoted by the United Nations Environment Programme (UNEP)1Guidelines for Social Life Cycle Assessment, UNEP, 2009. It can be applied to nanomaterials and must be conducted prospectively, prior to commercialization – not in “firefighting mode” after health or environmental problems have arisen. This is a broader “benefit-risk” analysis than that commonly proposed by proponents of the traditional (and limited) risk assessment approach. In particular, it considers the following questions: “what benefits/risks, for whom, where, when?
At present, scientists have very limited knowledge of the types of nanomaterials that are incorporated into products currently on the market, and a fortiori of any degradation residues of nanomaterials released throughout the “life cycle” of these products; they also know little about their mobility and transformations in the environment or in the human body: many parameters come into play, such as the ageing of the nanomaterials2See for example Ageing influences the toxicity of two innovative nanofertilizers to the soil invertebrates Enchytraeus crypticus and Folsomia candida, C. Maleihro, Environmental Pollution, 350, Juin 2024, the degree of acidity or salinity of the water for example3On the influence of acidity on the physicochemical parameters of nanomaterials, see for example:
– Fate of iron nanoparticles in the environment. Colloidal stability, chemical reactivity and impacts on plants Edwige Demangeat’s thesis, Geosciences Rennes UMR 6118, 2018
– Natural acids in soil could protect rice from toxic nanoparticles, Science News, April 2015.
In May 2019, Science for Environment Policy reports on the progress of a life cycle assessment method tailored to emerging technologies: the Lifecycle Screening of Emerging Technologies (LiSET). Will it be usable and used before the marketing of certain “nanos”? The question needs to be investigated.
In French :
- “Exposure to nanomaterials must be assessed throughout the life cycle to design safer products,” points out Jérôme Rose, CNRS Silver Medal 2020, Industry & Technologies, May 25, 2021
- Management of waste and effluents containing nanomaterials. Fate and impact in the treatment and recovery processes – Summary Ecogeos, RECORD, 2019
- 3rd regional NEC (“nano eco design”) working group on “Eco-design of nanomaterials”, organized by Labex Serenade and Éa éco-entreprises in Aix-en-Provence: Life Cycle Assessment – for a “safer by design” approach, February 2019
- Assessment of the risks associated with nanomaterials – Issues and update of knowledge, ANSES, April 2014
- The life of nanomaterials… and ours? Nanotechnology Citizen’s Collective of the Plateau de Saclay, April 2014
- Legal reflections on the life cycle assessment of nanomaterials, Techniques de l’ingénieur, April 2014
In English:
- Nanosafety Analysis of Graphene-Based Polyester Resin Composites on a Life Cycle Perspective, Aznar Mollá, F et al, Nanomaterials, 12, 2036, 2022
- Morphological transformation of silver nanoparticles from commercial products: modeling from product incorporation, weathering through use scenarios, and leaching into wastewater, Mohan S et al, Nanomaterials, 9(9), 1258, 2019
- Environmental Life Cycle Assessment of Nanosilver-Enabled Bandages, Pourzahedi L and Eckelman MJ, ES&T, March 2015
- Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards
Wohlleben W et al, CRC Press, 2015 - Life Cycle Assessment of ‘Green’ Nanoparticle Synthesis Methods, Environmental Engineering Science, June 2014
- From Cradle-to-Grave at the Nanoscale: Gaps in U.S. Regulatory Oversight along the Nanomaterial Life Cycle, ES&T, May 2013
- LCA and Responsible Innovation of Nanotechnology, 2013
- NanoSustain Factsheet and Case Studies, 2013
- Analysis and strategic management of nanoproducts with regard to their sustainability potential Analysis and strategic management of nanoproducts with regard to their sustainability potential, Öko-Institut, July 2012
- Life cycle assessment of engineered nanomaterials, Science of The Total Environment, May 2012
Any questions or comments? This information sheet compiled by AVICENN is intended to be completed and updated. Please feel free to contribute.
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Upcoming Nano Agenda


- Webinar presenting the example guide produced by NanoMesureFrance, to illustrate the difficulties encountered in dimensional analysis of particles by electron and atomic force microscopy.
- Organizers: Eurotox
- Speaker: Carola Voss (Helmholtz Zentrum München)
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- MOOC from April 28 to June 22, 2025
- Public who has carried out two or more years of scientific studies at university, as well as professionals or the self-educated who want to discover, learn more or acquire specific knowledge in some area of nanoscience.
- Organizer: Paris Saclay University
- Course paln:
- Theme 1: Introduction to nanoscience and nanotechnology – Let’s lay the foundations and discover the key concepts of this field.
- Theme 2: How can you “see” and fabricate nano-objects? We will discover what tools are used to observe matter at these scales and what techniques the scientist can use to make objects that are only a few billionths of a meter in size.
- Theme 3: Nanochemistry – From carbon to porous solids and nanoparticle synthesis; applications of the field.
- Theme 4: Nanophysics – Quantum effects and nanoelectronic devices; optical nanostructures: the confinement of light and emission; nanosensors; applications of the field.
- Theme 5: Nanobiology, Nanomedicine, Micro-nanofluidics – The study and manipulation of molecules; treating diseases with nanomedicine; the on-chip manipulation of liquids for medical diagnosis; applications of the field.
- Theme 6: Nanoscience and Society: Are Nanotechnologies dangerous? Societal, health and environmental issues.
- Website: www.fun-mooc.fr/en/courses/understanding-nanosciences

- E-learning program: awareness-raising for personnel who come into contact with nanomaterials during research, formulation, production, maintenance, cleaning, upkeep, etc., as well as safety coordinators or engineers, facility managers, heads of laboratories where nanoparticles are handled.
- Organizers: INSTN Grenoble (CEA)
- On the program:
- 1 – Introduction, definition and characteristics of nanomaterials
- 2 – Toxicity of nanomaterials: the state of knowledge
- 3 – Metrology and characterization of nanomaterials
- 4 – Prevention and protection against nanomaterials in the workplace
- 5 – Quiz: assessment of learning outcomes
- The 2-hour course can be viewed for one month from the date of registration.
- Website: https://instn.cea.fr/…risques-lies-aux-nanomateriaux…
This sheet was originally created in November 2014
Notes and references
- 1
- 2See for example Ageing influences the toxicity of two innovative nanofertilizers to the soil invertebrates Enchytraeus crypticus and Folsomia candida, C. Maleihro, Environmental Pollution, 350, Juin 2024
- 3On the influence of acidity on the physicochemical parameters of nanomaterials, see for example:
– Fate of iron nanoparticles in the environment. Colloidal stability, chemical reactivity and impacts on plants Edwige Demangeat’s thesis, Geosciences Rennes UMR 6118, 2018
– Natural acids in soil could protect rice from toxic nanoparticles, Science News, April 2015