Silica, risks and health at work: update from INRS
INRS has published a practical safety sheet on synthetic amorphous silicas (SAS), their manufacture and use, their properties and hazards, as well as the prevention and protection measures to be implemented.
INRS reminds us that with 180,000 tons produced in France in 2019, SAS is one of the four most declared substances in the nanoparticulate state in the r-nano register. SAS primary particles have a diameter of less than 100 nm and are therefore, in the regulatory sense, “substances in a nanoparticulate state” or “nanomaterials”.
In short…
In vitro, SAS exerts a cytotoxic effect via oxidative stress and apoptosis (cell death). Precipitated and fumed silicas have also shown genotoxic effects (DNA breaks).
Only a few studies have looked at the carcinogenic effects of amorphous silicas, but the potential for cellular transformation as well as epigenetic effects have been reported for some.
In vivo, in rats, inhalation of amorphous silica causes pulmonary inflammation (reversible). In humans, irritation and dehydration of the mucous membranes of the nose and throat, aggravation of asthma or bronchitis, mechanical irritation and dehydration of the skin, redness and stinging of the eyes have been reported. The data are too insufficient to rule on the long-term effects of SAS on workers’ health. Hence the need to minimize occupational exposure to SAS.
The INRS practical sheet proposes detailed prevention measures adapted to each work situation:
Upcoming Nano Agenda
- Seminar presenting the Seirich system for chemical risk assessment, with a focus on the specificities of nanomaterials.
- Organizers: Association NanoMesureFrance
- Speakers: Florian Marc (INRS)
- Website: www.eventbrite.fr/e/billets-nanomesurefrance-webinar-1984136502691
- Toxicokinetics: the fate of chemicals in the body” training course:
- the different routes of entry for toxic products
- the importance of toxicokinetics in preventing substance toxicity,
- xenobiotic absorption, distribution, metabolism and elimination
- nanoparticle toxicity
- Organizer: Association Toxicologie Chimie (ATC)
- Date: March 26, 2026
- Speaker: Nicole Proust (Research Engineer, CNRS Honorary Research Director, Palaiseau)
- Website: www.atctoxicologie.fr/…
- Two days of information, discoveries and testimonials for occupational health and safety professionals, experts and enthusiasts to discuss chemical risk prevention in the workplace.
- Organizers: Association TOXILIST
- Website: https://toxidays.fr/